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Deliberations of an International Panel of Experts on OCT Angiography Nomenclature of Neovascular Age-Related Macular Degeneration

Published:December 23, 2020DOI:https://doi.org/10.1016/j.ophtha.2020.12.022
      OCT angiography (OCTA) has been used to identify and characterize macular neovascularization (MNV) secondary to age-related macular degeneration (AMD).
      • El Ameen A.
      • Cohen S.Y.
      • Semoun O.
      • et al.
      Type 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography.
      • Kuehlewein L.
      • Bansal M.
      • Lenis T.L.
      • et al.
      Optical coherence tomography angiography of type 1 neovascularization in age-related macular degeneration.
      • Sulzbacher F.
      • Pollreisz A.
      • Kaider A.
      • et al.
      Identification and clinical role of choroidal neovascularization characteristics based on optical coherence tomography angiography.
      • Spaide R.F.
      • Jaffe G.J.
      • Sarraf D.
      • et al.
      Consensus nomenclature for reporting neovascular age-related macular degeneration data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group.
      Many studies have explored OCTA morphologic features of MNV that might serve as biomarkers to assess disease activity and response to treatment.
      • El Ameen A.
      • Cohen S.Y.
      • Semoun O.
      • et al.
      Type 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography.
      • Kuehlewein L.
      • Bansal M.
      • Lenis T.L.
      • et al.
      Optical coherence tomography angiography of type 1 neovascularization in age-related macular degeneration.
      • Sulzbacher F.
      • Pollreisz A.
      • Kaider A.
      • et al.
      Identification and clinical role of choroidal neovascularization characteristics based on optical coherence tomography angiography.
      • Spaide R.F.
      • Jaffe G.J.
      • Sarraf D.
      • et al.
      Consensus nomenclature for reporting neovascular age-related macular degeneration data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group.
      • Coscas G.J.
      • Lupidi M.
      • Coscas F.
      • et al.
      Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge.
      • Miere A.
      • Semoun O.
      • Cohen S.Y.
      • et al.
      Optical coherence tomography angiography features of subretinal fibrosis in age-related macular degeneration.
      However, the proliferation of studies has resulted in OCTA terminology that has been variable and inconsistent. To address the inconsistency of nomenclature and to allow harmonization, a multidisciplinary panel of retinal imaging experts with a history of relevant research contributions to the field was assembled with the purpose to review published terminology and to recommend a reduced list of key terms pertinent to OCTA. The group was called UNICORN, because of its ultimate goal of generating a UNIfied COmmentary of the committee of inteRnational experts on the nomenclature for Neovascular AMD in OCTA. In this report, we describe the first steps of this process, which included a review of OCTA descriptors of neovascular AMD published to date and an exercise that tested agreement of these terms among retinal imaging experts.

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