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Evaluating Amblyopia Treatment Success Using the American Academy of Ophthalmology IRIS50 Measures

Published:January 28, 2020DOI:https://doi.org/10.1016/j.ophtha.2020.01.041
      There are few consensus measures of treatment success for amblyopia. Most published studies measure relative improvement in visual acuity (VA) without establishing concrete success criteria. Furthermore, there is inconsistency in outcome measures and reporting timelines among investigators.
      • Al Jabri S.
      • Kirkham J.
      • Rowe F.J.
      Development of a core outcome set for amblyopia, strabismus and ocular motility disorders: a review to identify outcome measures.
      Definitive measures of success may better inform individual practitioners of their performance while allowing for assessment of new treatment strategies. The American Academy of Ophthalmology developed criteria for measuring amblyopia treatment success (known as IRIS7), recently modified in 2019 (IRIS50). In patients aged 3 to 7 years with starting interocular difference (IOD) >0.29 logarithm of the minimum angle of resolution (logMAR), success was defined as having final IOD <0.23 logMAR, final VA of 20/30 or better (≤0.18 logMAR), or VA improvement of 2 or more lines (≥0.18 logMAR) in the affected eye at 3 to 12 months follow-up (AAO 2019).
      In this study, we report our amblyopia treatment outcomes based on the IRIS50 and IRIS7 measures and evaluate the predictive value of multiple baseline variables.

      Abbreviations and Acronyms:

      ICD9 (International Classification of Diseases 9th Revision), IOD (interocular difference), logMAR (logarithm of the minimum angle of resolution), LTFU (lost to follow-up), VA (visual acuity)
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