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Conjunctival Stromal Tumor: Expansion of Findings in a Newly Described Entity

Published:January 08, 2016DOI:https://doi.org/10.1016/j.ophtha.2015.11.027
      Conjunctival myxoma is a rare benign tumor that accounts for <0.001% of conjunctival lesions.
      • Shields C.L.
      • Demirci H.
      • Karatza E.
      • Shields J.A.
      Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumors.
      It is important to recognize this entity, because it might be associated with cardiac myxoma, which can be life threatening.
      • Herwig M.C.
      • Wells J.R.
      • Grossniklaus H.E.
      Conjunctival stromal tumor: report of 4 cases.
      Based on a series of 4 cases, Herwig et al
      • Herwig M.C.
      • Wells J.R.
      • Grossniklaus H.E.
      Conjunctival stromal tumor: report of 4 cases.
      recently described the new entity, the conjunctival stromal tumor (COST), with its name deduced from the well-known gastrointestinal stromal tumor, showing a partially similar immunomarker profile. Positive markers for COST include CD34, vimentin, and partially for CD68; negative markers include S100 and smooth muscle actin. Gastrointestinal stromal tumor often are CD34+, and sometimes positive for S100 and smooth muscle actin.
      • Fletcher C.D.M.
      • Berman J.J.
      • Corless C.
      • et al.
      Diagnosis of gastrointestinal stromal tumors: a consensus approach.
      Myxomas are CD34 (unpublished data, September 2013, and the case described herein).
      • Lapp T.
      • Birnbaum F.
      • Evert M.
      • et al.
      Corneal tumour following anterior chamber lens implantation in a patient with Marfan syndrome. Case study of a 57-year-old patient.
      Herein we have reported 3 further cases of COST with the purpose of adding these to the spectrum of its clinical and histologic appearances.
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