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Comparison of Two Questionnaires for Dry Eye Symptom Assessment

The Ocular Surface Disease Index and the Symptom Assessment in Dry Eye

      Purpose

      The aim of this study was to compare patient-reported symptoms of dry eye disease (DED) as assessed by the Ocular Surface Disease Index (OSDI), a 12-item symptom frequency–based questionnaire, and the Symptom Assessment iN Dry Eye (SANDE), a 2-item frequency- and severity-based visual analog scale.

      Design

      Clinic-based evaluation of a diagnostic test.

      Participants

      A total of 114 patients with DED.

      Methods

      Patients were administered the OSDI and SANDE questionnaires at baseline and follow-up visits to evaluate DED-related symptoms. The correlations between both questionnaires' scores were evaluated using the Spearman coefficient, and their clinical differences were assessed using Bland–Altman analysis.

      Main Outcome Measures

      Baseline and follow-up visit OSDI and SANDE dry eye symptom scores.

      Results

      At the baseline visit, the OSDI and SANDE questionnaire scores were significantly correlated (R = 0.64; P < 0.001). Moreover, a significant correlation was found between changes in the OSDI and SANDE scores from baseline to follow-up visits (R = 0.47; P < 0.001). A Bland–Altman analysis, after score normalization, revealed a difference (bias) of less than 2 centesimal units between the scores of the 2 questionnaires.

      Conclusions

      Data collected from the SANDE questionnaire showed a significant correlation and negligible score differences with those from the OSDI, suggesting that the SANDE visual analog scale–based questionnaire has the potential to provide clinicians with a short, quick, and reliable measure for DED symptoms.

      Abbreviations and Acronyms:

      CFS (corneal fluorescein staining), DED (dry eye disease), OSDI (Ocular Surface Disease Index), SANDE (Symptom Assessment iN Dry Eye)
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