Advertisement

Alcohol Consumption and Risk of Cataract Extraction

A Prospective Cohort Study of Women
Published:December 14, 2006DOI:https://doi.org/10.1016/j.ophtha.2006.07.046

      Purpose

      To investigate the association between alcohol consumption and the risk of cataract extraction.

      Design

      Population-based prospective cohort study.

      Participants

      A total of 34 713 women participating in the Swedish Mammography Cohort, age 49 to 83 years, completed in 1997 a self-administered questionnaire about alcohol, smoking, and other lifestyle factors.

      Methods

      The women were followed from September 1997 through September 2004. The cohort was matched with registers of cataract extraction from the study area.

      Main Outcome Measures

      Incident surgical extraction of age-related cataract.

      Results

      During 84 months of follow-up, we found 3587 incident cases of age-related cataract extraction. Compared with never drinkers, the relative risk of cataract extraction among current drinkers was 1.11 (95% confidence interval [CI] 1.02–1.21) after adjustment for age and other potential risk factors. In multivariate analysis, an increment of 13 g alcohol intake per day (corresponding to 1 drink = 330 ml of beer, 150 ml of wine, or 45 ml of liquor) was associated with a 7% increased risk of cataract extraction (relative risk, 1.07; 95% CI 1.02–1.12). Mean age at cataract extraction among nonsmoking women who used alcohol was 75 years, compared with 77.6 years among never drinkers.

      Conclusions

      These prospective data suggest that daily use of ≥1 alcoholic drinks was associated with a modest increase of risk for cataract extraction. The risk increased with increasing alcohol consumption.
      To read this article in full you will need to make a payment
      Subscribe to Ophthalmology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Italian-American Cataract Study Group
        Risk factors for age-related cortical, nuclear, and posterior subcapsular cataracts.
        Am J Epidemiol. 1991; 133: 541-553
        • Age-Related Eye Disease Study Research Group
        Risk factors associated with age-related nuclear and cortical cataract: a case-control study in the Age-Related Eye Disease Study.
        Ophthalmology. 2001; 108: 1400-1408
        • Delcourt C.
        • Cristol J.P.
        • Tessier F.
        • et al.
        Risk factors for cortical, nuclear, and posterior subcapsular cataracts: the POLA Study.
        Am J Epidemiol. 2000; 151: 497-504
        • Dolin P.
        Epidemiology of cataract.
        in: Johnson G.J. Weale R. Minassian D.C. The Epidemiology of Eye Disease. Chapman & Hall, New York1998: 103-118
        • Hirvela H.
        • Luukinen H.
        • Laatikainen L.
        Prevalence and risk factors of lens opacities in the elderly in Finland: a population-based study.
        Ophthalmology. 1995; 102: 108-117
        • Hodge W.G.
        • Whitcher J.P.
        • Satariano W.
        Risk factors for age-related cataracts.
        Epidemiol Rev. 1995; 17: 336-346
        • Klein B.E.
        • Klein R.
        • Lee K.E.
        • Meuer S.M.
        Socioeconomic and lifestyle factors and the 10-year incidence of age-related cataracts.
        Am J Ophthalmol. 2003; 136: 506-512
        • Klein B.E.
        • Klein R.
        • Moss S.E.
        Incident cataract surgery: the Beaver Dam Eye Study.
        Ophthalmology. 1997; 104: 573-580
        • Leske M.C.
        • Chylack Jr, L.T.
        • He Q.
        • et al.
        • LSC Group
        Risk factors for nuclear opalescence in a longitudinal study.
        Am J Epidemiol. 1998; 147: 36-41
        • Leske M.C.
        • Chylack Jr, L.T.
        • Wu S.Y.
        The Lens Opacities Case-Control Study: risk factors for cataract.
        Arch Ophthalmol. 1991; 109: 244-251
        • McCarty C.A.
        • Nanjan M.B.
        • Taylor H.R.
        Attributable risk estimates for cataract to prioritize medical and public health action.
        Invest Ophthalmol Vis Sci. 2000; 41: 3720-3725
        • Tsai S.Y.
        • Hsu W.M.
        • Cheng C.Y.
        • et al.
        Epidemiologic study of age-related cataracts among an elderly Chinese population in Shih-Pai, Taiwan.
        Ophthalmology. 2003; 110: 1089-1095
        • Harding J.J.
        • van Heyningen R.
        Beer, cigarettes and military work as risk factors for cataract.
        Dev Ophthalmol. 1989; 17: 13-16
        • Jacques P.F.
        • Chylack Jr, L.T.
        • McGandy R.B.
        • Hartz S.C.
        Antioxidant status in persons with and without senile cataract.
        Arch Ophthalmol. 1988; 106: 337-340
        • Harding J.J.
        • van Heyningen R.
        Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide.
        Br J Ophthalmol. 1988; 72: 809-814
        • Ritter L.L.
        • Klein B.E.
        • Klein R.
        • Mares-Perlman J.A.
        Alcohol use and lens opacities in the Beaver Dam Eye Study.
        Arch Ophthalmol. 1993; 111: 113-117
        • Manson J.E.
        • Christen W.G.
        • Seddon J.M.
        • et al.
        A prospective study of alcohol consumption and risk of cataract.
        Am J Prev Med. 1994; 10: 156-161
        • Cumming R.G.
        • Mitchell P.
        Alcohol, smoking, and cataracts: the Blue Mountains Eye Study.
        Arch Ophthalmol. 1997; 115: 1296-1303
        • Clayton R.M.
        • Cuthbert J.
        • Duffy J.
        • et al.
        Some risk factors associated with cataract in S.E. Scotland: a pilot study.
        Trans Ophthalmol Soc U K. 1982; 102: 331-336
        • Munoz B.
        • Tajchman U.
        • Bochow T.
        • West S.
        Alcohol use and risk of posterior subcapsular opacities.
        Arch Ophthalmol. 1993; 111: 110-112
        • Phillips C.I.
        • Clayton R.M.
        • Cuthbert J.
        • et al.
        Human cataract risk factors: significance of abstention from, and high consumption of, ethanol (U-curve) and non-significance of smoking.
        Ophthalmic Res. 1996; 28: 237-247
        • Flaye D.E.
        • Sullivan K.N.
        • Cullinan T.R.
        • et al.
        Cataracts and cigarette smoking: the City Eye Study.
        Eye. 1989; 3: 379-384
        • Mohan M.
        • Sperduto R.D.
        • Angra S.K.
        • et al.
        India-US case-control study of age-related cataracts.
        Arch Ophthalmol. 1989; 107: 670-676
        • Tavani A.
        • Negri E.
        • La Vecchia C.
        Food and nutrient intake and risk of cataract.
        Ann Epidemiol. 1996; 6: 41-46
        • Chasan-Taber L.
        • Willett W.C.
        • Seddon J.M.
        • et al.
        A prospective study of alcohol consumption and cataract extraction among U.S. women.
        Ann Epidemiol. 2000; 10: 347-353
        • Ejdervik Lindblad B.
        • Hakansson N.
        • Svensson H.
        • et al.
        Intensity of smoking and smoking cessation in relation to risk of cataract extraction: a prospective study of women.
        Am J Epidemiol. 2005; 162: 73-79
        • Lundström M.
        • Stenevi U.
        • Thorburn W.
        The Swedish National Cataract Register: a 9-year review.
        Acta Ophthalmol Scand. 2002; 80: 248-257
        • Colenbrander A.
        Preservation of vision or prevention of blindness.
        Am J Ophthalmol. 2002; 133: 263-265
        • Cox D.R.
        Regression models and life-tables.
        J R Stat Soc Ser B. 1972; 32: 187-220
        • Morris M.S.
        • Jacques P.F.
        • Hankinson S.E.
        • et al.
        Moderate alcoholic beverage intake and early nuclear and cortical lens opacities.
        Ophthalmic Epidemiol. 2004; 11: 53-65
        • Rothman K.J.
        • Greenland S.
        Precision and validity in epidemiologic studies.
        in: Rothman K.J. Greenland S. Modern Epidemiology. 2nd ed. Lippincott Raven, Philadelphia1998: 115-134
        • Gerster H.
        Antioxidant vitamins in cataract prevention.
        Z Ernahrungswiss. 1989; 28: 56-75
        • Zima T.
        • Fialová L.
        • Mestek O.
        • et al.
        Oxidative stress, metabolism of ethanol and alcohol-related diseases.
        J Biomed Sci. 2001; 8: 59-70
        • Cordova A.C.
        • Jackson L.S.
        • Berke-Schlessel D.W.
        • Sumpio B.E.
        The cardiovascular protective effect of red wine.
        J Am Coll Surg. 2005; 200: 428-439
      1. World Health Organization Programme for the Prevention of Blindness and Deafness. Global initiative for the elimination of avoidable blindness. Geneva: World Health Organization 1997:1–14. WHO/PBL/97.61 rev 1. Available at: http://whqlibdoc.who.int. Accessed September 29, 2006.